Stem Cell Skincare: Calecim Skilled Serum Assessment

October 3, 2022 0 Comments

This put up is sponsored by Calecim however all opinions are 100% sincere and my very own. This put up comprises affiliate hyperlinks, and every buy helps cowl the
price of operating this weblog at no further price to you! Full disclosure

Whereas I don’t imagine good skincare must be costly, typically paying a premium for breakthrough components and expertise could also be price it. I’ve talked about development components as one such ingredient, and personally had nice outcomes with sure manufacturers. This goes to indicate the significance of high quality R&D on an ingredient’s efficacy.

The Calecim Skilled Serum not solely comprises development components however a number of proteins from stem cells to rejuvenate the pores and skin. Let’s see if it lives as much as the excessive worth!


What’s it
Highest focus of stem cell derived development components and proteins, anti-inflammatory components, cytokines and anti-rejection components which might be physiologically balanced to assist activate tissue renewal, cut back process downtime and discomfort, and optimizes aesthetic outcomes.

Finest suited to
Mature pores and skin varieties (30+ people), these with pimples scarring, eczema, irritation, or simply had laser therapy and wish to assist with wound therapeutic.

Issues to notice
None, comprises solely conditioned media from ethically sourced umbilical wire lining stem cells.

5ml serums are available in individually sealed packets for optimum freshness. The cap should be eliminated and changed with the pipette cap earlier than use. There’s additionally 1.5ml serums which might be accessible as items with buy throughout promos, and these come as single-use glass ampoules that should be snapped open every time.

Accommodates no synthetic perfume, however it naturally has a yeast-like scent. Dissipates after software. 

Looks like water with a touch of slip. The colour needs to be pink which implies the product is on the right pH degree.

Pure end with no shine or stickiness.

Accessible For
$100 for single 5ml on Calecim Official Web site (15% off with code JENNY). It can save you extra by shopping for a number of and subscribing: 2 for $170 or 5 for $420, further 20% in the event you setup auto-replenish.

Calecim Serum Components

Aqua, Hyaluronic Acid, Glycoproteins, 1,2-Hexanediol, Soluble Collagen, Albumin, Fibronectin

You’ll discover that “stem cells” aren’t listed within the components, and that’s as a result of it’s the energetic components derived from stem cells (wire lining stem cells to be actual) that work their magic. Calecim’s guardian firm CellResearchCorp has been researching the appliance of stem cells in topical skincare for over 10 years and have developed their signature CALECIM® Rejuvenating Conditioned Media which incorporates the next: 

  • Hyaluronic Acid – an exquisite humectant that’s naturally present in our pores and skin.
  • Glycoproteins – A kind of peptide that’s additionally a pure a part of our pores and skin. It really works with different components like hyaluronic acid to bolster our pores and skin’s barrier and maintain it easy and wholesome1. In addition they act as development issue reservoirs, that are then launched after proteolysis, or the breakdown of the protein4. Progress components then set off a cell signaling cascade that stimulates cell development and restore!
  • Collagen – Whereas this ingredient gained’t straight add to the collagen ranges in our pores and skin, it does work as a wonderful humectant to maintain the pores and skin hydrated.
  • Albumin – A protein additionally present in egg whites and a movie former, which may make your pores and skin really feel tight2. It’s really a fairly necessary protein in our physique performing many vital features, however from a skincare perspective the advantages are restricted.
  • Fibronectin – A protein that’s discovered to assist with wound therapeutic when utilized topically on the pores and skin3. There’s additionally some proof that along with development components the results on pores and skin therapeutic are enhanced.5

Stem cell sourcing

So no, you’re not getting precise umbilical wire bits in your serum. And no, these components aren’t derived from human umbilical cords both, however from crimson deer ethically and organically raised in a New Zealand farm. Umbilical cords present the richest supply of stem cells and are the least invasive as they are often collected naturally throughout delivery, in contrast to bone marrow or fats tissue stem cells which could be extremely painful for the animal to extract. Using deer is to stop the transmission of any ailments from the animal again to us (so no pigs or cows).

Calecim has sourced one umbilical wire from these deer (throughout a pure delivery, the place it’d be tossed as waste by the vets in any other case), and from this one wire there are 12 billion stem cells, that are then put into an answer to launch the components above. They usually’ve been utilizing this identical wire since they began promoting their product, speak about sustainability! 


      This serum can be utilized from twice a day as an intensive therapy earlier than main occasions to simply as soon as per week as a pores and skin booster to assist the bottle last more. 

      1. Use instantly after cleaning and drying your pores and skin. A water-based exfoliating toner could also be used earlier than to reinforce product absorption. The pores and skin needs to be oil-free earlier than making use of the serum.
      2. Draw up one full pipette and gently press the product into your pores and skin. I prefer to heat my arms earlier than as the warmth can even assist with product absorption. Calecim Professional Serum application
      3. Observe with the remainder of your routine (toner, serum, moisturizer, and so forth).


You may also use an at-home micro-needling machine beforehand to assist enhance product absorption.

Utilization Expertise & Outcomes

✅ Simple to include into any routine

Irrespective of your pores and skin sort or present routine, the Calecim Skilled Serum will match proper in because of its elegant texture and easy components. Different EGF serums are usually thicker and comprise further moisturizing, which may make layering tough and even result in pilling.

Since this serum has minimal components in a water-based resolution, there’s no concern of components or textures clashing. And since you solely want the tiniest bit (I imply take a look at the tiny dropper) to see outcomes, feeling smart it’s such as you didn’t apply something in any respect.

Calecim Professional Serum texture

✅ Noticeable outcomes after 1-2 bottles

Given the worth per bottle, I’d be offended if I noticed no outcomes. However instantly my pores and skin feels smoother after one software, and after about 1.5 bottles, I seen general pores and skin well being enhancements reminiscent of much less noticeable high quality strains + pores and a brighter, extra even complexion.

Take into accout that is used along with my common vitamin c within the am + retinol within the pm. As promising as stem cells and development components sound, it’s nonetheless necessary to have your skincare routine primarily based on well-researched and time confirmed components. Consider the Calecim Skilled Serum because the (very scrumptious) icing on the cake that takes your routine to the following degree.

✅ Excellent for holidays, earlier than large occasions, or put up facial remedies

I introduced a bottle with me to Greece and it lasted me a whole week whereas taking on nearly no area in my make-up bag. It additionally helped maintain my pores and skin in prime situation regardless of jet lags and much, LOTS of solar (and warmth and alcohol and sugar and all kinds of not-so-good issues). Because you see outcomes shortly with the Calecim Serum, they’re additionally good for prepping your pores and skin earlier than particular events – eg. a marriage!

Whereas I haven’t personally examined utilizing this after in-clinic remedies (ie. lasers or micro-needling), Calecim has labored with docs to conduct scientific trials on its efficacy in lowering redness and rushing up the therapeutic course of, and the outcomes are extraordinarily promising.

How to use the Calecim Professional Serum

❌ Exhausting to justify common use given the worth

Regardless that I used to be lucky sufficient to obtain these for evaluate, I’ll be sincere and admit the worth blew my thoughts, and never in a great way. I perceive the R&D behind the ingredient is a motive for the excessive price, however on the identical time, it’s simply not one thing the common individual can afford.

For many of us with a funds, this or any costly EGF skincare are positively not necessities. You’ll be able to nonetheless see nice outcomes with reasonably priced, tried-and-true components!

What Others Say

I had critical eczema signs from the withdrawal of utilizing topical steroid lotions. The folds of my arms, backs of my knees even my eyelids and face swollen crimson and uncooked. the Calecim serum has principally turned my pores and skin again to regular ….in solely 4 days of use.


The stem cell serum and multi-action cream are very soothing, particularly after having laser remedies, they appear to speed up the therapeutic course of. The one motive I give them 4 stars as a substitute of 5 is due to the excessive price


Finest serum ever! It absorbs actually quick into my pores and skin and leaves no sticky sensation. I really like making use of it after a deep cleanse at night time and I get up with glowing and rejuvenated pores and skin.


Calecim Skilled Serum In contrast

Klairs Midnight Blue Youth Activating Drops
An reasonably priced different for day by day use, the Klairs options 95% EFG + and likewise is available in a water-like method that’s straightforward so as to add to any routine. At 1/10 of the worth don’t count on the identical outcomes although. It gained’t have the identical post-facial therapeutic impact and it took me ending a whole bottle of the Klairs and taking a break to note a slight distinction. However with continued utilization you may get 80% comparable enhancements additional time.

SkinMedica TNS+ Superior Serum
Additionally costly, however nonetheless 1/2 of Calecim in the event you think about the worth per ml. This has a typical serum texture and whereas I’ve no points layering this in my dry pores and skin routine, it positively feels extra substantial. I began noticing a distinction about midway by means of the bottle. It has a tremendous mix of anti-aging components, however they do supply their development components from cells from the neonatal foreskin.

Babor Energetic Night time Ampoules
Completely different components however comparable claims of rejuvenating the pores and skin utilizing a excessive focus of energetic components. Besides these Babor ampoules had been complete flops. Possibly their different ampoules are higher however in the event you’re spending your cash, I’d somewhat you spend $100 on one thing that truly works than $40 on one thing that doesn’t.

my cat reaching for the Calecim Professional Serum
Apparently my cat has very costly style in skincare

Closing Verdict

  • Components
  • Packaging
  • Texture/Utility
  • Efficiency
  • Worth

It is uncommon to see a product with such fast outcomes, so I am positively impressed. I additionally admire how clear they’re about their stem cell supply and their effort to ethically and sustainably purchase the components.

BUT, I am additionally all about practicality, and as a lot as I beloved the outcomes, I believe there are higher choices in your cash for on a regular basis use. Now in the event you’re planning to get laser therapy or in the event you simply wish to pamper your pores and skin earlier than a giant occasion and have the funds, attempt a couple of bottles and prepare to be impressed.

Article Sources

To maintain my content material correct and reliable, I depend on peer-reviewed research, articles from respected tutorial establishments, and quotes from licensed healthcare professionals to again my claims. No woo-woo clickbait nonsense right here!

  1. “Glycoproteins | Paula’s Selection.”, Paula’s Selection Skincare, 2022,

  2. Jacques, Renee. “Korean Egg Pores and skin Care Merchandise.” Attract, Attract, 23 Feb. 2016,

  3. Johnson, Maxwell B., et al. “Topical Fibronectin Improves Wound Therapeutic of Irradiated Pores and skin.” Scientific Reviews, vol. 7, no. 1, June 2017,

  4. Pfisterer, Karin, et al. “The Extracellular Matrix in Pores and skin Irritation and An infection.” Frontiers in Cell and Developmental Biology, vol. 9, July 2021,

  5. Patten, Jennifer, and Karin Wang. “Fibronectin in Improvement and Wound Therapeutic.” Superior Drug Supply Critiques, vol. 170, Mar. 2021, pp. 353–68,

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